From NFL Week 3 clashes and high-stakes college football to WNBA playoffs, MLB pennant races, Formula 1 in Baku, NASCAR playoffs, and Wrestlepalooza, this weekend (Sept 18–22, 2025) delivers non-stop action for sports fans and bettors alike.
Betting Recap & Sports Update for the Week with MyBookie
Check out this weekend’s top sports events.
NFL Week 3 Games
Thursday, September 18 – Miami Dolphins at Buffalo Bills (-11.5)
The Bills look to assert dominance in the AFC East, while the Dolphins aim for their first win of the season.
Sunday, September 21 – Key Matchups
Falcons -5.5 at Panthers: NFC South rivals clash with young QBs looking to control the division.
Packers -7.5 at Browns: Green Bay’s passing attack faces a tough Cleveland defense.
Texans at Jaguars -1.5: AFC South battle could set an early tone in the standings.
Bengals at Vikings -3.5: Browning’s Bengals face J.J. McCarthy and a tough Minnesota test.
Steelers -1.5 at Patriots: Two proud franchises meet in a defensive showdown.
Rams at Eagles -3.5: LA’s youth challenges the defending Super Bowl champs in Philly.
Jets at Buccaneers -6.5: Jets look to prove progress against a strong Tampa squad.
Colts -3.5 at Titans: Indy’s revamped offense hopes to drop Cam Ward and the Titans to 0-3.
Raiders at Commanders -3.5: Both teams seek consistency in this matchup of rising offenses.
Saints at Seahawks -7.5: Saints aim to play spoiler to Sam Darnold and Seattle.
Cowboys at Bears -1.5: Caleb Williams seeks his first win against Dak and Dallas.
Cardinals at 49ers -1.5: Injury-plagued San Francisco tries to hold off Kyler Murray.
Sunday Night Football – Chiefs -5.5 at Giants
Patrick Mahomes leads the champs into New York, while Russell Wilson and the Giants try to pull off the upset.
Monday, September 22 – Lions at Ravens -4.5
A heavyweight AFC clash with physical teams and explosive offenses. Bettors eyeing the total may lean toward the over.
College Football – Saturday, September 20
Top Matchups
Texas Tech vs. Utah: Big 12 showdown with major conference implications.
Auburn at Oklahoma: SEC grit meets Big 12 firepower in Norman.
Michigan at Nebraska: Classic Big Ten battle with Michigan slight road favorites.
South Carolina at Missouri: SEC East clash with Missouri entering as double-digit favorites.
Florida at Miami: Rivalry game with HC Billy Napier’s future potentially on the line.
Illinois at Indiana: Hoosiers favored despite Illinois’ top-ten ranking.
WNBA Playoffs – Friday, September 19
Golden State Valkyries at Minnesota Lynx
A physical playoff contest where the Lynx seek to defend home court against Golden State.
New York Liberty at Phoenix Mercury
Two title hopefuls collide as both teams fight to keep championship dreams alive.
MLB Series – Starting Friday, September 19
Seattle Mariners vs. Houston Astros
AL West crown hangs in the balance as two rivals collide in a crucial series.
San Francisco Giants vs. Los Angeles Dodgers
One of baseball’s biggest rivalries shapes the NL West playoff picture.
Motorsports – Sunday, September 21
Formula 1 – Azerbaijan Grand Prix (Baku)
High-speed street drama as McLaren looks to defend its lead against Red Bull and Max Verstappen.
NASCAR Cup Series Playoffs – New Hampshire
Playoff intensity rises as drivers battle for advancement points in a key postseason race.
Wrestling – Saturday, September 20
Wrestlepalooza
Over-the-top action and entertainment highlight a night of spectacle beyond traditional sports.
Bettors can explore props for winners, specialty matches, and more.
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