A loaded pre-holiday weekend hits with NFL Week 16, the College Football Playoff First Round, a blockbuster boxing main event, plus key NBA and NHL matchups. Here’s everything to watch and bet on at MyBookie.
Top Sports of the Weekend — December 18 to December 21, 2025
NFL Week 16 – December 18–22, 2025
Thursday, Dec. 18
Los Angeles Rams at Seattle Seahawks — 8:15 p.m. ET (Prime Video)
The NFC West title is on the line when Matthew Stafford and the Rams take on Sam Darnold and the Hawks in Seattle. Which team takes a step closer to the division crown?
Saturday, Dec. 20
- Philadelphia Eagles at Washington Commanders — 5:00 p.m. ET (FOX) — A meaningless game for the Commanders has a lot on the line for the Eagles. Philly ended a three-game losing streak in NFL Week 15. If Jalen Hurts and the Birds can keep it going, the NFC East is still theirs for the taking.
- Green Bay Packers at Chicago Bears — 8:20 p.m. ET (FOX) — The Bears lead the division, which makes this a must-win for the Packers. Can Green Bay’s defense slow Ben Johnson’s play-calling genius without top defender Micah Parsons? That’s the story for Jordan Love and company.
Sunday, Dec. 21 – Early Window
- Buffalo Bills at Cleveland Browns — 1:00 p.m. ET (CBS) — Shedeur Sanders gets another chance to prove he’s a legitimate NFL QB. This time, he faces a surging Bills defense that dominated Drake Maye and the Patriots in Week 15.
- Los Angeles Chargers at Dallas Cowboys — 1:00 p.m. ET (FOX) — Dallas’ slim playoff hopes could slip away when the Cowboys host a Chargers team coming off a stunning road win over Kansas City. L.A. is trending up.
- Kansas City Chiefs at Tennessee Titans — 1:00 p.m. ET (CBS) — KC’s playoff hopes are finished, and Patrick Mahomes is out for the season. With no reason to push veterans, the Titans look like the sharp side.
- Cincinnati Bengals at Miami Dolphins — 1:00 p.m. ET (CBS) — This matchup could swing either way. Miami’s speed, especially Devon Achane, could overwhelm a Bengals defense that struggled mightily in Week 15.
- Minnesota Vikings at New York Giants — 1:00 p.m. ET (FOX) — JJ McCarthy heads to the Meadowlands after his best pro performance. McCarthy vs. Jaxon Dart is fun, even if the stakes are low.
- Tampa Bay Buccaneers at Carolina Panthers — 1:00 p.m. ET (FOX) — The Panthers and Bucs battle for the NFC South crown. One of the league’s weakest divisions could still be won with nine losses.
Sunday, Dec. 21 – Late Window
- Jacksonville Jaguars at Denver Broncos — 4:05 p.m. ET (FOX) — A playoff-implication showdown between two of the NFL’s hottest teams. Denver’s defense is elite, but Trevor Lawrence and the Jaguars are rolling.
- Atlanta Falcons at Arizona Cardinals — 4:05 p.m. ET (FOX) — Little meaning here unless you’re betting. Fantasy-wise, Jacoby Brissett throwing to Trey McBride could be worth monitoring.
- Pittsburgh Steelers at Detroit Lions — 4:25 p.m. ET (CBS) — Both teams are in must-win mode. Detroit fights for a wild card while Pittsburgh tries to stay ahead of Baltimore in the AFC North.
- Las Vegas Raiders at Houston Texans — 4:25 p.m. ET (CBS) — Houston is rolling on both sides of the ball. With C.J. Stroud clicking again, the Texans look like a legitimate Super Bowl contender.
Sunday Night Football — Dec. 21
New England Patriots at Baltimore Ravens — 8:20 p.m. ET (NBC)
How will Drake Maye respond after a rough second half against Buffalo? Baltimore enters off its most complete performance of the season.
Monday Night Football — Dec. 22
San Francisco 49ers at Indianapolis Colts — 8:15 p.m. ET (ABC/ESPN/Disney+)
Philip Rivers nearly sparked a comeback in Seattle last week, but the 10–4 49ers are pushing toward the playoffs. A critical spot for both teams.
🏈 College Football Playoff — First Round
Friday, Dec. 19
#9 Alabama vs #8 Oklahoma
A heavyweight CFP opener. Alabama must establish the run to flip the script from the earlier matchup.
Saturday, Dec. 20 — Tripleheader
#10 Miami vs #7 Texas A&M
Explosive offense meets SEC physicality. Miami has upset potential if the Aggies’ late-season struggles continue.
#11 Tulane vs #6 Ole Miss
Ole Miss’ offense could overwhelm Tulane, which surrendered over 30 points multiple times during AAC play.
#12 James Madison vs #5 Oregon
Oregon lays a big number, but James Madison’s veteran defense makes taking the points appealing.
🥊 Boxing — Friday, Dec. 19
Jake Paul vs Anthony Joshua — Miami (Netflix)
A watershed moment for Jake Paul against a true heavyweight. Win or lose, this fight reshapes his boxing legacy.
⚽ NHL Weekend
Carolina Hurricanes at Florida Panthers — Friday, Dec. 19
A potential Eastern Conference Finals preview between two Cup contenders.
Vegas Golden Knights at Edmonton Oilers — Sunday, Dec. 21
A marquee Western Conference clash between two teams that believe they can lift the Cup.
🏀 NBA Weekend
Oklahoma City Thunder at Minnesota Timberwolves — Friday, Dec. 19
Minnesota’s defense tests the Thunder after OKC’s first stumble of the season.
Houston Rockets at Denver Nuggets — Saturday, Dec. 20
A Western Conference showdown. Houston’s defense and scoring depth make this dangerous for Denver.
Bottom Line
With NFL Week 16 playoff stakes, the College Football Playoff First Round, a major boxing showdown, and premium NBA and NHL action, this is one of December’s most action-packed sports weekends. Lock in your plays early and monitor the live boards — momentum is everywhere at MyBookie.